Results: SATB2 single stain showed a good sensitivity of 83% and the highest specificity of 78% for AMNs over OMNs among all four stains. DS with SATB2 and villin showed an identical sensitivity

Negative for SATB2 Contains a characteristic gene rearrangement (EWSR1-ETS transcription factor) Osteochondroma (may be in differential with parosteal osteosarcoma): Bone contiguous with native marrow Intramedullary space filled with fat and hematopoietic elements (not spindle cells)

Geisinger Medical Laboratories offers histologic preparation and immunohistochemistry with a large menu of special stains, including HER-2/neu, p21ras, p-Akt,  Slide Slide SAS (Glass Syndrome) SATB2-associated Syndrome Is a rare, genetic disorder characterized by significant developmental delay with limited to   The Hematoxylin and Eosin (H&E) method is the routine, recognized stain used within histology laboratories; however, many other special tinctorial stains are  was established to enrich the lives of individuals with SATB2-associated syndrome, including those diagnosed with the condition and their families, through  Sierra Stain® Reactive Acid Stain. Available in 9 standard colors; A concentrated penetrating reactive stain that chemically combines with cured concrete to  AFB Stains & Stain Sets. Reduce False Positives. Sputum smear microscopy remains a widely used diagnostic for AFB. Of the 767 million patient evaluations  Iron, Trichrome).

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Complete information for SATB2 gene (Protein Coding), SATB Homeobox 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium Triple Stain PSA PSAP/HPAPMLH1 PSMA PTH RCC1 S100 ESCC (Esophageal) S100p SALL4 SATB2(PASD+PAS) Serotonin. Reticulin SF1 SMA SMMHC Smoothelin Somatostatin SSTR2 (Somatostatin Receptor, Type 2) SOX2 SOX10 SOX11 STAT6 Surfactant TCL1 TCR BetaF1 TCR Delta Thrombomodulin (TM) Thyroglobulin (TGB) TIA1 Test Code SATB2 SATB2 Immunostain, Technical Component Only Advisory Information This test includes only technical performance of the stain (no pathologist interpretation is performed). Immunohistochemistry and special stains play an increasingly important role in gastrointestinal pathology practice.

Invitrogen Anti-SATB2 Monoclonal (CL0276), Catalog # MA5-31339. Tested in Western Blot (WB) and Immunohistochemistry (Paraffin) (IHC (P)) applications.

2021-02-25 SATB2 : Identification of colorectal carcinoma and rectal neuroendocrine tumors SATB2 - Overview: SATB2 Immunostain, Technical Component Only Skip to main content Objectives: Small sample size limits the number of immunostains that may be attempted in colorectal carcinoma (CRC) biopsy specimens. We investigated the SATB2 : Special AT-rich sequence binding protein 2 (SATB2) is a transcription factor that regulates gene expression through chromatin remodeling. SATB2, when used in combination with the marker Keratin 20, may identify more than 95% of colorectal carcinoma. It may also be used to differentiate rectal neuroendocrine tumors from other neuroendocrine tumors of the gastrointestinal tract.

Coomassie Staining as Loading Control in Western Blot Analysis SATB2 in Combination With Cytokeratin 20 Identifies Over 95% of all Colorectal Carcinomas.

Western (B) Representative immunofluorescent staining of SATB2 in proliferating and  Feb 2, 2021 Cytoskeletal staining of zebrafish melanoma in vitro cultures (Zmel1 MCR:EGFP and 45–3 MCR:SATB2) with phalloidin revealed the presence  Anti-SATB2 antibody produced in rabbit (Anti-APXL3 ); Prestige Antibodies to be used according to the standard IHC staining protocol described below.

SATB2 stains colonic and osteogenic cells and their neoplasms.
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(FFPE) human tissues. The clinical interpretation of any staining or its . Feb 2, 2021 Cytoskeletal staining of zebrafish melanoma in vitro cultures (Zmel1 MCR:EGFP and 45–3 MCR:SATB2) with phalloidin revealed the presence  Dec 20, 2019 SATB2 restrains induction of muscle cell differentiation.

Zaibo Li et al. Am J Clin Pathol (2018) 149: 241-246. Clinicopathological, immunohistochemical and mutational analyses of pulmonary enteric adenocarcinoma: Usefulness of SATB2 and β-catenin immunostaining for differentiation from metastatic colorectal carcinoma.
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Results Positive SATB2 immunoreactivity was observed in 23 (46%) SIAs in contrast to 48 (96%) CRCs (p<0.0001). Among these, only 4 (8%) SIAs showed strong and diffuse (4+) SATB2 staining compared with 38 (76%) of CRCs (p<0.0001). Conclusions SATB2 is not entirely CRC-specific and is expressed in a subset of SIAs.

Stains included in this group are as follows: Alcian Blue, Alcian Blue PAS, Alizarin Stain for Hemoglobin (Okajama's), Alkaline Congo Red for  Jan 1, 2015 They also studied SATB2 expression in a large number of human carcinomas. Positive nuclear stain was found in 1336 of 1558 primary colon  Monoclonal Antibody for studying SATB2 in the Chromatin Regulation / Epigenetics Non-specific non-nuclear staining was observed in smooth muscle . SATB2 is a biomarker for colorectal cancer, 85% of all CRC patients are positive for SATB2 and other cancer types rarely display SATB2 expression SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas ( Am J Surg Pathol 2011;35:937 ) SATB2 : Identification of colorectal carcinoma and rectal neuroendocrine tumors For each additional technical component only IHC stain performed, an additional Abstract. SATB2 is part of the family of matrix attachment region-binding transcription factors, and has developmental roles in craniofacial, neural, and osteoblastic differentiation. Recently, SATB2 has been shown to be highly expressed in the epithelium of the lower gastrointestinal tract, with a relatively narrow expression profile in malignancies, including colorectal/appendiceal adenocarcinomas, tumors of osteoblastic differentiation, and renal/urothelial carcinomas. SAT B2 A formalin-fixed, paraffin-embedded (FFPE) tissue block is preferred specimen type or One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides Block and slide identifiers should be clearly written and match exactly with the Value of SATB2 immunostaining in the distinction between small intestinal and colorectal adenocarcinomas. SATB2 is not entirely CRC-specific and is expressed in a subset of SIAs.

2018-06-15 · However, 2 deletions did not include the SATB2 gene and did not overlap, indicating that other genes proximal and distal to SATB2 contribute to the phenotype. Using comparative genomics, Rainger et al. (2014) identified 3 different functional enhancing cis-regulatory elements (CREs) in the gene desert between the PLCL1 and SATB2 genes, 3-prime to SATB2.

Immunohistochemistry (IHC) and special stains are indispens- able adjuncts in the reporting of gastrointestinal   of SATB2 protein by immunohistochemistry (IHC) in formalin-fixed paraffin- embedded.

Three quarters of gastric primaries stain for CDX2 and only rare examples stain for SATB2. Colorectal primaries (most of them) and appendiceal primaries (all of them) are positive for CDX2 and SATB2. GATA3 stains almost all breast primaries and approximately half of bladder primaries.